Carbohydrate heterobifunctional cross-linking reagent

Details Carbohydrate heterobifunctional cross-linking reagent Carbohydrate heterobifunctional cross-linking reagent

1992-04-16

1995-05-02

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 552, C07H 504, C07H 506, C08B 3708

Patent

active

054120837

ABSTRACT:
A heterobifunctional cross-linking reagent having a carbohydrate backbone (derived from a chitin substrate) is disclosed. The cross-linker is available in a variety of lengths, is highly water-soluble, and can be formulated to undergo cleavage catalyzed by the enzyme lysozyme.

REFERENCES:
Davies et al, "[52] Determination of the Degree of Acetylation of Chitin and Chitosan", Methods in Enzymology 161:442-446 (1988).
Hirano, "[45] Water-Soluble Glycol Chitin and Carboxymethylchitin", Methods in Enzymology 161:408-410 (1988).
Muzzarelli, "Chitin", Pergamon Press, pp. 119-120 (1977).
Ohtakara, "[49] Viscosimetric Assay for Chitinase", Methods in Enzymology 161:426-430 (1988).
Pietersz, "The Linkage of Cytotoxic Drugs to Monoclonal Antibodies for the Treatment of Cancer", Bioconjugate Chemistry 1(2):89-95 (1990).
Wong, "Chemistry of Protein Conjugation and Cross-Linking", CRC Press, Inc. Table of Contents and p. 153.
Yamada et al, "A convenient synthesis of glycolchitin, a substrate of lysozyme" Carbohydrate Research 92:160-162 (1981).
Chemical Abstracts, vol. 104, No. 19, issued 12 May 1986, Hirano et al, "Preparation of Acetylated Derivatives of Modified Chito-oligosaccharides by the Depolymerization of Partially N-acetylated Chitosan with Nitrous Acid" see p. 698, col. 2, Abstract No. 168720z, Carbohydr. Res. 1985, 144(2), 338-41 (Eng).

Affiliated with

Also associated with

Rating

Carbohydrate heterobifunctional cross-linking reagent does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Carbohydrate heterobifunctional cross-linking reagent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carbohydrate heterobifunctional cross-linking reagent will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1138189