Carbohydrate glass matrix for the sustained release of a therape

Details Carbohydrate glass matrix for the sustained release of a therape Carbohydrate glass matrix for the sustained release of a therape

1993-07-13

1994-10-18

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424423, 424425, 424426, 424488, 424468, 514 2, 5147722, 5147723, 514777, 514783, 514786, 514785, 514787, A61K 914, A61K 3702, A61K 3736, A61K 4726

Patent

active

053566351

ABSTRACT:
A composition for the sustained release of a biologically active therapeutic agent wherein the matrix of the sustained release composition is composed of an amorphous carbohydrate glass matrix comprising a suitable carbohydrate and an agent which retards the recrystallization of the carbohydrate and a biologically active therapeutic agent and a water-insoluble wax dispersed throughout the matrix. Biologically active therapeutic agents which can be incorporated into the carbohydrate glass matrix include prolactin, growth hormones, serum albumins, growth factors or any biologically active fragment or recombinant form thereof.

REFERENCES:
patent: 2413419 (1946-12-01), Saunders et al.
patent: 4590062 (1986-05-01), Jang
patent: 4671953 (1987-06-01), Stanley et al.
patent: 4765980 (1988-08-01), DePrince et al.
patent: 4857506 (1989-08-01), Tyle
patent: 5219572 (1993-06-01), Sivaramakrishnan et al.
patent: 5266333 (1993-11-01), Cady et al.

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