Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1995-03-31
1999-03-30
McKane, Joseph
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
5303911, 5303913, 5303915, 5303917, 5303919, 530395, 530396, 530397, 530398, 514 8, 514 12, 514 21, 424 851, 4241781, 4241791, 4241941, 42419511, C07K 1514
Patent
active
058891552
ABSTRACT:
The invention provides heterobifunctional cross-linking reagents and methods of using the cross-linking reagents. The cross-linking reagents of the invention combine a nucleophilic hydrazide residue with an electrophilic maleimide residue, allowing coupling of aldehydes to free thiols. In the methods of the invention, human immunodeficiency virus (HIV) infected cells can be detected using conjugates that include CD4 molecules conjugated to detectable markers via the disclosed cross-linking reagents.
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Ashkenazi Avi J.
Chamow Steven M.
Kogan Timothy P.
Conley Deirdre L.
Dreger Ginger R.
Genentech Inc.
Marschang Diane L.
McKane Joseph
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