Carbohydrate-directed cross-linking reagents

Details Carbohydrate-directed cross-linking reagents Carbohydrate-directed cross-linking reagents

1992-08-05

1994-07-12

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548536, 548547, 548549, C07D207452

Patent

active

053290283

ABSTRACT:
The invention is from the field of heterobifunctional cross-linking reagents. More particularly, the invention concerns cross-linking reagents which combine a nucleophilic hydrazide residue with an electrophilic maleimide residue, thereby allowing coupling of aldehydes to free thiols.

REFERENCES:
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Heindel, N. D. et al., Bioconjugate Chem. 2, 427-430 (1991).
Ji, T. H., Meth. Enzymol. 91, 580-609 (1983).
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Rodwell, J. D., Proc. Natl. Acad. Sci. USA 83, 2632-2636 (1986).
Traut, R. R., et al., Biochemistry 12, 3266-3275 (1973).
Webb, R. R. II, and Kaneko, T. Bioconjugate Chem. 1, 96-99 (1990).
Zara, J. J. et al. Anal. Biochem. 194, 156-162 (1991).

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