Carbohydrate derivatives of milbemycin and processes therefor

Details Carbohydrate derivatives of milbemycin and processes therefor Carbohydrate derivatives of milbemycin and processes therefor

1977-11-17

1979-05-29

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 17R, 536 4, A61K 3170, C07G 1100

Patent

active

041567200

ABSTRACT:
Carbohydrate derivatives of the antibiotic substance milbemycin, also identified as B-41, and of 13-hydroxy milbemycin are prepared. The carbohydrate groups are attached to the available hydroxy groups of milbemycin and to the hydroxy group synthesized at the 13-position. The reactions may be made selectively such that more than one carbohydrate group may be attached to a single position, or that multiple carbohydrate groups may be attached at different positions on the molecule. The described carbohydrate derivatives have antiparasitic activity.

REFERENCES:
patent: 3356674 (1967-12-01), Ikeda et al.
patent: 3950360 (1976-04-01), Aoki et al.
patent: 3984564 (1976-10-01), Aoki et al.

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