Carbohydrate conjugates as inhibitors of cell adhesion

Details Carbohydrate conjugates as inhibitors of cell adhesion Carbohydrate conjugates as inhibitors of cell adhesion

1995-07-31

1999-01-12

LeGuyader, John L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 54, 536 111, 536 551, 536 552, 5361231, 435 71, A01N 4304, C07H 100, C07H 504, G01N 3353

Patent

active

058589945

ABSTRACT:
The invention relates to novel conjugates of tetrasaccharides, preferably of sialyl-Lewis X (SLeX) and sialyl-Lewis A (SLeA), having improved activity as inhibitors of cell adhesion, a process for the preparation of these compounds, and their use as pharmacological active compounds and as diagnostics and pharmaceuticals which contain these conjugates.

REFERENCES:
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Toyokuni et al., "Synthetic Vaccines: Synthesis of a Dimeric Tn Antigen-Lipopeptide Conjugate That Elicits Immune Responses Against Tn-Expressing Clycoproteins," J. Am. Chem. Soc., 119: 395-396 (1994).

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