Carbohydrate analog inhibitors of alpha-amylase

Details Carbohydrate analog inhibitors of alpha-amylase Carbohydrate analog inhibitors of alpha-amylase

2008-01-22

2008-01-22

Zucker, Paul A. (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C560S251000, C560S252000, C564S457000

Reexamination Certificate

active

07320998

ABSTRACT:
The present invention provides carbohydrate analogs of the formula:wherein X is CH2, O, or NH, and R1-8are independently H, a short hydrocarbon, a substituted amine, an alcohol, a substituted ether, a substituted amide, a substituted ketone, a substituted carboxylic acid, a short peptide, or a short oligosaccharide, Y is H, a short hydrocarbon, a short peptide, or a short oligosaccharide, and R9is H, a short hydrocarbon, a substituted amine, an alcohol, a substituted ether, a substituted amide, a substituted ketone, a carboxylic acid, a short peptide, or a short oligosaccharide.

REFERENCES:
patent: 4174439 (1979-11-01), Rauenbusch et al.
patent: 4946925 (1990-08-01), Strohmayer et al.
Fischer S. Influence of treatment with acarbose or glibenclamide on insulin sensitivity in type 2 diabetic patients.Diabetes Obes Metab.2003;5:38-44.
Hauner H. Effect of acarbose on weight maintenance after dietary weight loss in obese subjects.Diabetes Obes Metab.2001;3:423-7.

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