Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1994-01-27
1997-09-02
Cintins, Marianne M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
560116, 562503, 562507, 564 80, 564 90, 564 92, 564 95, A61K 31215, A61K 3118, C07C 69608
Patent
active
056634170
ABSTRACT:
(1) Prostaglandin (PG) E.sub.2 antagonist or agonist containing carbocyclic sulfonamides represented by the compound of the formula (I): ##STR1## cyclodextrin clathrates thereof, non-toxic salts thereof as active ingredient, (2) carbocyclic sulfonamides represented by the compound of the formula (II): ##STR2## cyclodextrin clathrates thereof, non-toxic salts thereof, (3) process for the preparation of the compound represented by the compound of the formula (II) described hereinbefore, (4) PGE.sub.2 antagonist or agonist containing the compound represented by the compound of the formula (II) as active ingredient.
The compounds represented by the compounds of the formula (I) and (II) can be adapted to medicines which possess an inhibitory effect of uterine contraction, an analgetic action, an inhibitory effect of digestive peristalsis, a sleep-inducing effect as PGE.sub.2 antagonists, and an uterine contractile activity, a promoting effect of digestive peristalsis, a suppressive effect of gastric acid secretion, a hypotensive activity as PGE.sub.2 agonists, because they bind onto PGE.sub.2 receptor and have an activity of antagonist or agonist against the action thereof.
REFERENCES:
patent: 4861913 (1989-08-01), Narisada
patent: 5168101 (1992-12-01), Arai et al.
16th International Symposium on the Chemistry of Natural Products Abstracts p. 453, (1988), Lieb et al.
Hamanaka Nobuyuki
Miyamoto Tsumoru
Cintins Marianne M.
Jones Dwayne C.
Ono Pharmaceutical Co. Ltd.
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