Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2006-01-03
2006-01-03
Barts, Samuel (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C564S310000, C562S590000, C562S582000, C562S586000, C562S584000, C562S595000, C514S554000, C514S574000
Reexamination Certificate
active
06982286
ABSTRACT:
The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-I (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The novel compounds have the general formula:or a pharmaceutically acceptable solvate, hydrate, or salt thereof wherein R1to R11are as defined herein.
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Alaranta Sakari
Fülöp Ferenc
Lázár László
Pihlavisto Marjo
Smith David John
Barts Samuel
Biotie Therapies Corp.
Sterne Kessler Goldstein & Fox P.L.L.C.
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