Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2010-08-19
2011-12-20
Loewe, Sun Jae (Department: 1622)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S210180, C514S239500, C514S327000, C514S330000, C514S331000, C514S424000, C514S429000, C514S432000, C514S459000, C514S622000, C544S159000, C546S221000, C546S225000, C546S234000, C548S578000, C548S950000, C548S541000, C548S953000, C564S177000, C549S424000, C549S028000
Reexamination Certificate
active
08080541
ABSTRACT:
The present invention relates to the use of a compound of formula Iwherein R1, R2, R3, R4, X and n are as defined hereinor to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomers and/or optical isomers for the treatment of psychoses, pain, dysfunction in memory and learning, attention deficit, schizophrenia, dementia disorders or Alzheimer's disease.
REFERENCES:
patent: 4215114 (1980-07-01), Szmuszkovic
patent: 2749984 (1978-05-01), None
Cherney et al., caplus an 2004:701975.
Lewis D.A. & Lieberman J. A., Neuron. vol. 28, pp. 325-334 (2000).
Vandenberg R. J. & Aubrey K. R., Exp. Opin. Ther. Targets vol. 5(4) pp. 507-518 (2001).
Nakazato A. & Okuyama S., Exp. Opin Ther. Patents vol. 10(1) pp. 75-98 (2000).
Sharma T., Br. J. Psychiatry, vol. 174 (Suppl. 38) pp. 44-51 (1999).
Javitt D. C. et al., Biol. Psychiatry, vol. 45 pp. 668-679 (1999).
Mohn A. R. et al., Cell, vol. 98 pp. 427-436 (1999).
Bliss, T. V. & Collingridge G. L., Nature, vol. 361 pp. 31-39 (1993).
Tang J. P. et al., Nature, vol. 401, pp. 63-69 (1999).
Gainetdinov R. R. et al., Trends in Pharm. Sci. vol. 23(8) pp. 367-373 (2002).
Lopez-Corcuera B, et al., Mol. Mem. Biol. vol. 18 pp. 13-20 (2001).
Bergeron R. et al., Proc. Natl. Acad. Sci. USA vol. 95, pp. 15730-15734 (1998).
Chen et al., J. Neurophysiol. vol. 89(2) pp. 691-703 (2003).
Armer R. E. & Miller D. J., Exp. Opin. Ther. Patents vol. 11(4) pp. 563-572 (2001).
Pralong E. et al., Prog. in Neurobiol. vol. 67, pp. 173-202 (2002).
Carlsson M. L. J. Neural Trans. vol. 105, pp. 525-535 (1998).
Yang et al., Bioorganic & Medicinal Chemistry (2000) vol. 8, No. 2 pp. 321-327.
Kolczewski Sabine
Pinard Emmanuel
Hoffman-La Roche Inc.
Johnston George W.
Loewe Sun Jae
Prior Kimberly J.
Rocha-Tramaloni Patricia S.
LandOfFree
Carbocyclic GlyT-1 receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Carbocyclic GlyT-1 receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carbocyclic GlyT-1 receptor antagonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4263001