Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1989-04-12
1992-03-10
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
5142375, 514255, 514319, 514423, 544159, 544391, 546205, 548540, 560315, A61K 31535, C07D295112
Patent
active
050950380
ABSTRACT:
This invention comprises novel carbocyclic compounds of formula I (wherein A, Z, R.sup.11 and R.sup.12 are defined in the specification) derived from acylsulfonamide derivatives of .alpha.-carbocyclyltoluic acids wherein said compounds of formula I antagonize the actions of one or more of the arachidonic acid metabolites known as leukotrienes. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
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Brown Frederick J.
Maduskuie, Jr. Thomas P.
Matassa Victor G.
Yee Ying K.
Haley Jacqueline
ICI Americas Inc.
Jackson Thomas E.
Lee Mary C.
Miano Rosemary M.
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