Carbocyclic analogues of thymine nucleosides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

544229, 544314, A61K 31505, C07D23926

Patent

active

047192143

ABSTRACT:
There are disclosed compounds having the formula: ##STR1## wherein R is a group having the formula --C.tbd.CSi(CH.sub.3).sub.3, --C.tbd.CH, --CH.dbd.CH.sub.2, --CH.sub.2 CH.sub.2 Si(CH.sub.3).sub.3 or --CH.sub.2 X; X is bromo, chloro or iodo; and R' is hydrogen or an acyl group, with the proviso that when R is --CH.sub.2 X, R' is an acyl group. Certain of these compounds are active in inhibiting the replication of DNA viruses. Other of these compounds are useful as intermediates in the production of compounds which are active in inhibiting the replication of DNA viruses.

REFERENCES:
patent: 4396623 (1983-08-01), Shealy et al.
patent: 4415573 (1983-11-01), Ochi et al.
patent: 4564618 (1986-01-01), Scopes et al.
Shealy and Clayton, Journal of the American Chemical Society, vol. 88, pp. 3885-3887, 1966.
C. Desgranges et al., (Biochemical Pharmacology, vol. 32, pp. 3583-3590, 1983).
R. Kaul, K. Keppeler, G. Kiefer, B. Hempel, and P. Fischer, (Chemosphere, vol. 11, pp. 539-540, 1982).
Y. F. Shealy and C. A. O'Dell, Journal of Heterocyclic Chemistry, vol. 13, pp. 1041-1047 (1976).
Shealy, O'Dell and Thorpe, Journal of Heterocyclic Chemistry, vol. 18, pp. 383-389 (1981).
Shealy, O'Dell, Thorpe and Coburn, Jr. Journal of Heterocyclic Chemistry, vol. 20, pp. 655-661 (1983).
K. C. Murdock and R. B. Angier, Journal of the American Chemical Society, vol. 84, pp. 3758-3764.
Shealy et al., Journal of Medicinal Chemistry, vol. 26, pp. 156-161 (1983).
Jerry March, "Advanced Organic Chemistry," 2nd Ed., McGraw-Hill Book Co., 1977, New York, N.Y.
Jasenka Matulic-Adamic and Kyoichi A. Watanabe, J. Chem. Soc., Chem. Comm., 1985, pp. 1535-1536.
Shealy et al., Chemical Abstract, vol. 104 (1986): 69111v.
Maggiora et al., Chemical Abstracts, vol. 104, (1986): 130206y.
Shealy et al., Chemical Abstracts, vol. 104, (1986): 130207z.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Carbocyclic analogues of thymine nucleosides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Carbocyclic analogues of thymine nucleosides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carbocyclic analogues of thymine nucleosides will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-921334

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.