Carbocyclic analogs of uracil nucleosides as antiviral agents

Details Carbocyclic analogs of uracil nucleosides as antiviral agents Carbocyclic analogs of uracil nucleosides as antiviral agents

1981-08-26

1983-08-02

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544309, 544311, 544313, 544314, A61K 31505, C07D23910

Patent

active

043966233

ABSTRACT:
There is provided a method for the treatment of viral infections by treating a host animal with a pharmaceutically effective amount of a carbocyclic analog of a nucleoside represented by Formula I: ##STR1## wherein X is chlorine, bromine, iodine, a lower alkyl group or an amino group of the formula --NHR.sup.2 wherein R.sup.2 is a lower alkyl group; and R and R' can be the same or different members selected from the group consisting of hydrogen, an alkanoyl group or an aroyl group.

REFERENCES:
patent: 4177348 (1979-12-01), Shealy
patent: 4232154 (1980-11-01), Shealy et al.
Murdock et al., J. Am. Chem. Soc., 84, (1962), pp. 3758-3764.
"Acid-Catalyzed Cyclization of Alkoxyacryloylureas to 2,4(1H,3H)pyrimidinediones", Shealy et al.; J. Heterocyclic Chem., 13 (1976), pp. 1015-1020, 1041-1047, 1353-1354.
"Carbocyclic Analogs of Thymine Nucleosides & Related 1-Substituted Thymines", Shealy et al; J. Heterocyclic Chem., 18 (1981), pp. 383-389.
"Carbocyclic Analogs of Cytosine Nucleosides", Shealy et al.; J. Heterocyclic Chem., 17 (1980), pp. 353-358.

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