Carbocyclic analogs of purine ribofuranosides

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

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536 24, 536 26, 544264, 544265, 544267, 544277, C07D23900

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active

047287365

ABSTRACT:
There are disclosed carbocyclic analogs of 2-amino-6-substituted-purine ribofuranosides and 2-amino-6-substituted-8-azapurine ribofuranosides. These compounds are useful in the treatment of viral infections.

REFERENCES:
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patent: 4268672 (1981-05-01), Vince
patent: 4383114 (1983-05-01), Vince
Journal of Pharmaceutical Sciences, vol. 62, pp. 1432-1434, 1973.COPYRGT., Y. F. Shealy and J. D. Clayton.
Journal of Pharmaceutical Sciences, vol. 69, pp. 1019-1021, 1980, H. Lee and R. Vince.
Shealy et al., Carbocyclic Analogs of Guanosine and 8-Azaguanosine, J. Pharm. Sciences, 62, 1432 (1973.COPYRGT.).
Lee et al., Carbocyclic Analogs of Arabinosylpurine Nucleosides, J. Pharm. Sciences, 69, 1019 (1980).
Shealy et al., Carbocyclic Analog of Purine Ribonucleosides with Antileukemic Activity, Chem. Abstracts, 79:100484k (1973a).
Shealy et al., Carbocyclic Analogs of 6-Substituted Purine Ribonucleosides and of Adenosine Ribonucleotides, Chem. Abstracts, 79:92531f (1973b).
Vince et al., Carbocyclic Arabinosyladenine . . . , Chem. Abstracts, 86:165109f (1977).

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