Carbocyclic adenosine analogs useful as immunosuppressants

Details Carbocyclic adenosine analogs useful as immunosuppressants Carbocyclic adenosine analogs useful as immunosuppressants

1994-05-12

1996-05-07

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514303, 514307, 514310, 546113, 546117, 546118, 546119, 546139, 546143, C07D23500, C07D22100, A61K 3141

Patent

active

055146880

ABSTRACT:
This invention relates to carbocyclic adenosine compounds of the formula (1) ##STR1## wherein the hydroxy substituent on the cyclopentanyl ring is in the CIS configuration relative to the bicyclic substituent,
Y.sub.3, Y.sub.7, Y.sub.8 and Y.sub.9 are each independently nitrogen or a CH group,
Q is NH.sub.2, halogen or hydrogen, and
Z is hydrogen, halogen, or NH.sub.2 ;
or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.

REFERENCES:
patent: 3917837 (1975-11-01), Lin et al.
patent: 4076711 (1978-02-01), Ganguly et al.
patent: 4386093 (1983-05-01), Chiang et al.
patent: 4387228 (1983-06-01), Montgomery et al.
patent: 4742064 (1988-05-01), Vince et al.
patent: 4845215 (1989-07-01), Shimada et al.
patent: 4859677 (1989-08-01), Borchardt et al.
patent: 4916224 (1990-04-01), Vince et al.
patent: 4954504 (1990-09-01), Chen et al.
patent: 4968674 (1990-11-01), Taniyama et al.
patent: 4997924 (1991-03-01), Jarvi et al.
patent: 5039689 (1991-08-01), Daluge
patent: 5126452 (1992-06-01), Vince et al.
Trost, et al., J. Am. Chem. Soc. vol. 110, 621-622, (1988).
Hasobe, et al., FASEB Journal vol. 4, A1771 (Abstr. #455) (1990).
Ault-Riche, et al., FASEB Journal vol. 4, A2050 (Abstr. #2064) (1990).
Wolfe, et al., 199th ACS National Meeting, Boston, Mass., Apr. 1990, Abstract #27.
Koga, et al., Tetrahedon Letters, vol. 31, No. 41, pp. 5861-5864, 1990.
A Dictionary of immunology, Herbert et al., pp. 112, 1989.
Dictionary of Immunology, Rosen et al., ed, 1989, pp. 9, 18, 69-70, 155, 188.
Recent Advantages in Immunology, Muftuoglu et al., ed., 1984, Plenum Press, pp. 191-209.
Introduction to Human Immunology, Huffer et al., 1986, pp. 148-161, 169-176.
Derwent Abstract 70718Y/40, (1977).
Derwent Abstract 70719Y/40, (1976).
Rousseau, R. J., and Robins, R. K., J. Hetero. Chem., 2, 196, (1965).

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