Carbocation scavenging during oligonucleotide synthesis

Details Carbocation scavenging during oligonucleotide synthesis Carbocation scavenging during oligonucleotide synthesis

1994-07-07

1996-04-23

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, 536 2533, 536 2534, C07H 100, C07H 2100, C07H 2104, C07H 2102

Patent

active

055104762

ABSTRACT:
During the synthesis of oligonucleotides and phosphate linked oligomers, a carbocation scavenging agent is employed to increase the overall yield. The carbocation scavenging agent is used in conjunction with an acidic solution employed during the deprotection step.

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