Carbo-acyclic nucleoside derivatives as antiviral and antineopla

Details Carbo-acyclic nucleoside derivatives as antiviral and antineopla Carbo-acyclic nucleoside derivatives as antiviral and antineopla

1996-05-31

2000-01-25

Dees, Jose'G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544276, 544265, 544277, 544264, 544314, 544317, 544318, 546118, 546119, 5483074, 5483097, 5483101, 5483104, 5483044, 514274, 514261, 514262, 514303, 514394, 514395, 514300, A61K 3152, C07D47318

Patent

active

060179236

ABSTRACT:
##STR1## The present invention is directed to a class of novel carbocyclic derivatives having formulas (I) and (II) and their use as anti-viral and anti-neoplastic agents, wherein X.sub.1 and X.sub.2 are each independently hydrogen, fluorine, or chlorine, R is hydrogen or hydroxymethyl, J is a radical of formulas (a), (b) and (c). Y.sub.1 is a CH group, a CCl group, a CBr group or a CNH.sub.2 group, Y.sub.2 and Y.sub.3 are each independently nitrogen or a CH group, Y.sub.1 is a CH group, a CCl group, a CBr group or a CNH.sub.2 group, Y.sub.2 and Y.sub.3 are each independently nitrogen or a CH group, Y.sub.4 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or halogen, Y.sub.5 is NH.sub.2 or C.sub.1 -C.sub.4 alkoxy, Q is NH.sub.2, NHOH, NHCH.sub.3, OH, or hydrogen, and V is hydrogen, halogen or NH.sub.2 ; or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4199575 (1980-04-01), Gunther et al.
patent: 4221794 (1980-09-01), Simon et al.
patent: 4355032 (1982-10-01), Verheyden et al.
patent: 4798833 (1989-01-01), Johansson et al.
patent: 4935427 (1990-06-01), Border et al.
patent: 5043339 (1991-08-01), Beauchamp
Bestman, et al., Agnew Chem. Int. Ed. Engl 29:(1):99-100 (1990).
McCarthy, et al., Tetrahedron Letters 31(38):5449-5452 (1990).
Edwards, et al., Tetrahedron Letters 31(39):5571-5574 (1990).
McCarthy, et al., J. Am. Chem. Soc. 113:7439-7441 (1991).
Ziegler, et al., J. Am. Chem. Soc. 115:2581-2589 (1993).
Mori, et al., Tetrahedron, 35:933-940 (1979).
Chan, et al., J. Org. Chem. 43(8): 1526-32 (1978).
Speziale, et al., J. Am. Chem. Soc. 84:854-859 (1962).
Chu, et al., J. Heterocycl Chem. 23:289-317 (3/4, 1986).
Brown, et al., Synthetic Procedures in Nucleic Acid Chemistry, vol. 1 (Zorbach & Tipson eds.), pp. 98-99.
Overberger, et al., Tetrahedron Letters, 30(1):51-54 (1989).

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