Carbazole derivatives and their use as 5HT-induced antagonists

Details Carbazole derivatives and their use as 5HT-induced antagonists Carbazole derivatives and their use as 5HT-induced antagonists

1986-07-23

1988-06-07

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548336, 548439, A61K 3140, C07D40306

Patent

active

047497181

ABSTRACT:
The invention relates to compounds of the general formula (I): ##STR1## wherein R.sup.1 represents a group CO.sub.2 R.sup.5, COR.sup.5, CONR.sup.5 R.sup.6 or SO.sub.2 R.sup.5 (wherein R.sup.5 and R.sup.6, which may be the same or different, each represents a hydrogen atom, a C.sub.1-6 alkyl or C.sub.3-7 cycloalkyl group, or a phenyl or phenyl-(C.sub.1-4)alkyl group in which the phenyl group is optionally substituted by one or more C.sub.1-4 alkyl, C.sub.1-4 alkoxy or hydroxy groups or halogen atoms, with the proviso that R.sup.5 does not represent a hydrogen atom when R.sup.1 represents a group CO.sub.2 R.sup.5 or SO.sub.2 R.sup.5);

REFERENCES:
patent: 3634420 (1972-01-01), Littell et al.
patent: 3671544 (1972-06-01), Meltzer et al.
patent: 4334070 (1982-06-01), Berger et al.
patent: 4740404 (1982-06-01), Littell et al.
R. Littell, E. N. Greenblatt and G. R. Allen, Jr., J. Med. Chem. 15(8) 875-6, 1972.
Evans, D. D., Aust. J. Chem.; 26(11), 2555-8, 1973.
J. C. Lancelot, et al., Chem. & Pharm. Bul., 1983, 31, 2652-2661.
Y. Oikawa et al., J. Org. Chem., 1977, 42, 1213-1216.

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