Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1990-09-10
1991-06-25
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
514534, C07C 6976
Patent
active
050268970
ABSTRACT:
Novel carbaphens are provided of the formula ##STR1## wherein R is OH, OCON(CH.sub.3).sub.2 or OCONHCH.sub.3, and R' is H, OH or sub.2 OCON(CH.sub.3).sub.2, stereoisomers thereof, pharmaceutically-acceptable salts thereof or mixtures thereof.
Compositions comprise the carbaphens with pharmaceutically acceptable carriers, and they may further comprise other drugs as well.
Methods of treating patients either prophylactically or therapeutically which suffer from organophosphate poisoning, coronary insufficiency, cerebral vasospasms, spastic cholitis and cholecystitis comprise the administration of the carbaphens of the invention.
REFERENCES:
Watts, C. et al, Mol. Pharmacol. 31(5) 541-51, 1987.
Dreyer, E. et al. J. Biol. Chem. 261(29) 13727-34 1986.
Banerjee, S. et al. Pharm. Res. 7(7) 746-50 1990.
Triggle, C. Con. J. Physiol. Pharmacol. 57(8) 804-8.
Chiang Peter K.
Doctor Bhupendra P.
Gordon Richard K.
Leader Haim
Padilla Felipe N.
Bellamy Werten F. W.
Killos Paul J.
Lane Anthony T.
The United States of America as represented by the Secretary of
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