Carbapenems, their production and use

Details Carbapenems, their production and use Carbapenems, their production and use

1984-09-28

1987-10-06

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540350, C07D48704, A61K 3140

Patent

active

046983392

ABSTRACT:
A compound of the general formula: ##STR1## wherein X is a lower alkylene group which may optionally be substituted by a hydroxyl group, or a lower alkenylene group, Y is (1) a lower alkyl group, (2) a cycloalkyl group containing 3 to 8 carbon atoms, (3) a lower alkenyl group, (4) an aryl group, (5) an aralkyl group or (6) a 3- to 8-membered heterocyclic group, or the partial structural formula Y--SO.sub.2 --X--, with X and Y being combined with each other, represents a group of the formula: ##STR2## wherein l is an integer of 0 to 3, and m and n each is an integer of 0 to 6, provided that the sum of m and n is in the range of 2 to 6, and R is a hydrocarbon group which may optionally be substituted or a 3- to 8-membered heterocyclic group, or a pharmaceutically acceptable salt thereof a method of production thereof and use thereof. The compound (I) has antimicrobial and .beta.-lactamase inhibitory activities.

REFERENCES:
patent: 4273709 (1981-06-01), Christenson et al.
patent: 4278686 (1981-07-01), Corbett et al.
patent: 4309346 (1982-01-01), Christenson et al.
Medicinal Chemistry-Alfred Burser, Interscience Publishers, N.Y., N.Y., 1960.

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