Carbapenem derivatives

Details Carbapenem derivatives Carbapenem derivatives

2005-06-21

2005-06-21

Chang, Celia (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S302000

Reexamination Certificate

active

06908913

ABSTRACT:
An objective of the present invention is to provide carbapenem derivatives which have strong antibiotic activity also against MRSA, PRSP, Influenzavirus, and β-lactamase producing bacteria and are stable to DHP-1. The carbapenem derivatives according to the present invention are compounds represented by formulae (I) and (II) or pharmaceutically acceptable salts thereof:wherein R1represents H or methyl, R2and R3each independently represent H; halogen; substituted or unsubstituted alkyl; cycloalkyl; substituted or unsubstituted alkylcarbonyl; carbamoyl; substituted or unsubstituted aryl; substituted or unsubstituted alkylthio; morpholinyl; alkylsulfonyl; or formyl, n is 0 (zero) to 4, and Hy represents a substituted or unsubstituted monocyclic or bicyclic heterocyclic group.

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patent: 6677331 (2004-01-01), Ida et al.
patent: 9948024 (2000-02-01), None
patent: 1022279 (2000-07-01), None
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patent: 01/55155 (2001-08-01), None
Wermuth “The practice of medicinal chemistry” Acad. Press, p. 203-237 (1996).

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