Carbapenem compounds and production thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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540350, C07D48704, A61K 3140

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active

049621033

ABSTRACT:
A compound of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group, R.sub.2 is a hydrogen atom or a conventional protecting group for a carboxyl group, R.sub.0 is a hydrogen atom or a conventional protecting group for a hydroxyl group, X is a protected or unprotected amino group, a carboxyl group, a lower alkoxycarbonyl group, an ar(lower)alkyloxycarbonyl group, a cyano group, a hydroxyl group, a lower alkyloxy group, a lower alkylthio group, a lower alkylsulfonyl group or a group of either one of the following formulas: ##STR2## wherein R.sub.3 and R.sub.4, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, or they are taken together to represent an alkylene chain to form, in combination with the adjacent nitrogen atom, a 3- to 7-membered cyclic amino group,

REFERENCES:
"Synthesis and in vitro Activity of a New Carbapenem, RS-533", The Journal of Antibiotics, pp. 1034-1039.
"Synthetic Carbapenem Antibiotics I.1-.beta.-methylcarbapenem", Heterocycles, pp. 29-40.

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