Carbapenem antibiotics

Details Carbapenem antibiotics Carbapenem antibiotics

1984-10-02

1987-07-28

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540310, 514210, C07D48704, A61K 3140

Patent

active

046833013

ABSTRACT:
Disclosed are novel carbapenem derivatives characterized by a 2-substituent of the formula ##STR1## wherein A represents C.sub.2 -C.sub.6 straight or branched chain alkylene group and R.sup.10 and R.sup.11 each independently represents optionally substituted aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aryl, heterocyclyl, heterocyclyl-aliphatic, heteroaryl or heteroaraliphatic, or R.sup.10 and R.sup.11 taken together with the S.sup..sym. to which they are attached represent an optionally substituted sulfur-containing heterocyclic ring. Such derivatives are useful as potent antibacterial agents. Also disclosed are processes for the preparation of such derivatives.

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Recent Advances in the Chemistry of .beta.-Lactam Antibiotics, The Royal Society of Chemistry, London, 1981, pp. 240-254.

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