Carbapenem antibiotics

Details Carbapenem antibiotics Carbapenem antibiotics

1985-09-11

1987-05-12

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D48704, A61K 3140

Patent

active

046651691

ABSTRACT:
Novel carbapenem antibiotics are prepared in which the 2-substituent has the formula ##STR1## wherein n is 0, 1, 2, 3, m, is 1 or 2, and R is C.sub.1 -C.sub.6 alkyl, allyl, propargyl, carboxymethyl, cyanomethyl or aralkyl wherein the aryl moiety is phenyl or heteroaryl and the alkyl moiety is C.sub.1 -C.sub.6 alkyl, said heterocyclic ring containing the sulfonium group being optionally substituted at a ring carbon atom or atoms by one or two C.sub.1 -C.sub.6 alkyl groups.

REFERENCES:
patent: 3950357 (1976-04-01), Kahan et al.
patent: 4232036 (1980-11-01), Christensen et al.
patent: 4235920 (1980-11-01), Christensen et al.
patent: 4309346 (1982-01-01), Christensen et al.
patent: 4536335 (1987-08-01), Kim et al.
Recent Advances in Chemistry of .beta.-Lactam Antibiotices, Royal Society of Chemistry, London, 1981, pp. 240-254.

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