Carbapenem antibiotics

Details Carbapenem antibiotics Carbapenem antibiotics

1985-08-05

1987-02-03

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

514210, C07D48704, A61K 3140

Patent

active

046407995

ABSTRACT:
Disclosed are novel carbapenem derivatives characterized by a 2-substituent of the formula ##STR1## in which A represents cyclopentylene, cyclohexylene or C.sub.2 -C.sub.6 alkylene optionally substituted by one or more C.sub.1 -C.sub.4 alkyl groups; R.sup.5 represents either (a) an optionally substituted aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aryl, araliphatic, heteroaryl, heteroaraliphatic, heterocyclyl or heterocyclyl-aliphatic radical or (b) a divalent phenylene or C.sub.1 -C.sub.4 alkylene group joined to the ##STR2## ring so as to form a bridged polycyclic group; and ##STR3## represents a quaternized nitrogen-containing non-aromatic heterocycle. Such derivatives are useful as potent antibacterial agents.

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Recent Advances in the Chemistry of .beta.-Lactam Antibiotics The Royal Society of Chemistry, London, 1981 pp. 240-254.
Handout at the Gordon Research Conference on Medicinal Chemistry held at New London, New Hampshire on Aug. 2-6, 1982.

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