Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-10-08
2000-10-31
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
51425402, 540302, 544368, A61K 31395, A01N 4360, C07D48700, C07D41300
Patent
active
061403180
ABSTRACT:
Compounds of formula I are disclosed. ##STR1## as well as pharmaceutically acceptable salts thereof. The naphthosultam is substituted with various substituent groups including at least one cationic group -A-Q-L-B.
The carbapenems of the invention are effective against susceptible bacterial organisms, including methicillin resistant Staphylococcus aureus (MRSA), methicillin resistant Staphylococcus epidermidis (MRSE), and methicillin resistant coagulase negative Staphylococci (MRCNS).
REFERENCES:
patent: 4309438 (1982-01-01), Christensen et al.
patent: 4479947 (1984-10-01), Christensen
patent: 5756725 (1998-05-01), Wilkening et al.
S. M. Schmitt et al. J. Antibiotics, 41(6), pp 780-787 (1988).
T. W. Green, Protective Group Inorganic Synethesis, Wiley, NY (1991).
Cama Lovji D.
Ratcliffe Ronald W.
Sun Wanying
Wildonger Kenneth J.
Wilkening Robert R.
Ayler Sylvia A.
Daniel Mark R.
Hunter, Jr. James M.
Merck & Co. , Inc.
Shah Mukund J.
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