Carbamoylpyrolidone derivatives and drugs for senile dementia

Details Carbamoylpyrolidone derivatives and drugs for senile dementia Carbamoylpyrolidone derivatives and drugs for senile dementia

1988-08-17

1990-12-11

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514342, 514343, 544295, 544316, 544364, 544372, 546 20, 546208, 546209, 546280, 546281, 548136, 548171, 548187, 548246, 548302, 548336, 548374, 548538, 5482676, A61K 31445, C07D40112

Patent

active

049771671

ABSTRACT:
A compound of the formula: ##STR1## (wherein R is phenoxy optionally substituted by a halogen, methoxy, or methyl group, ##STR2## one of A and B is ##STR3## and the other is >CH.sub.2 : R.sup.1 is hydrogen or C.sub.1 -C.sub.5 alkyl; Z.sup.1 is phenyl, benzyl, or isoxazolyl each optionally substituted by a halogen, methoxy, or methyl group; Z.sup.2 is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl, or phenyl optionally mono-, di-, or tri-substituted by a halogen, methoxy, or methyl group; or Z.sup.1 and Z.sup.2 taken together with the adjacent nitrogen atom may form 5-membered heterocyclic group; Z.sup.3 is C.sub.1 -C.sub.5 hydroxyalkyl, di(C.sub.1 -C.sub.5 alkyl)sulfamoyl, 6-membered heterocyclic group, phenyl, benzyl, or phenylsulfonyl each phenyl moiety of the last three members being optionally substituted by a halogen, methoxy, or methyl group; Z.sup.4 is phenyl optionally substituted by a halogen, methoxy, or methyl group or 5- or 6-membered heterocyclic group which is optionally substituted by a halogen, methoxy, or methyl group and which can be optionally condensed with a benzene ring; Z.sup.5 is thienyl or phenyl each optionally substituted by a halogen, methoxy, or methyl group; Z.sup.6 is thienyl or phenyl each optionally substituted by a halogen, methoxy, or methyl group; m is an integer from 0 to 2; n is an integer from 2 to 3) or its pharmaceutical acceptable acid addition salt being useful as a drug for senile dementia, psychotropic, or antiamnesia agent is provided through several routes.

REFERENCES:
patent: 2829146 (1958-04-01), Beaver et al.
patent: 4118396 (1978-10-01), Pifferi et al.
patent: 4145347 (1979-03-01), L'Italien et al.
patent: 4369139 (1983-01-01), Kyburz et al.
patent: 4670456 (1987-06-01), Weber et al.
patent: 4791112 (1988-12-01), Bagley et al.
Chemical Abstracts, vol. 87, No. 17, p. 217, Abstract No. 87:128886g.
Chemical Abstracts, vol. 91, No. 4, p. 611, Abstract No. 91:39238n.
Chemical Abstracts, vol. 95, No. 19, p. 719, Abstract No: 95:168964c.

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