Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-06-30
1998-12-08
Davis, Zinna Northington
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
544150, 544378, 546197, 5462681, 5483415, 549 13, C07D31102, A61K 31335
Patent
active
058471677
ABSTRACT:
Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions thereof are disclosed.
REFERENCES:
patent: 3631039 (1971-12-01), Andrews et al.
patent: 4088659 (1978-05-01), Bhat et al.
patent: 4118508 (1978-10-01), Bhat et al.
patent: 4134986 (1979-01-01), Bajwa et al.
patent: 4476140 (1984-10-01), Sears et al.
patent: 4517200 (1985-05-01), Kreutner et al.
patent: 4564626 (1986-01-01), Kreutner et al.
patent: 4639443 (1987-01-01), Kosley et al.
patent: 4639446 (1987-01-01), Kosley et al.
Calbiochem.RTM. Biochemical/Immunochemical Catalog, 1988 New Product Supplement, p. 18.
Biologics, 13, (No. 4), Oct. 1987.
Calbiochem.RTM. Biochemical/Immunochemical Catalog 1987, p. 102.
A. Laurenza, et al., Molecular Pharmacology, 32, 133 (1987) published in the U.S. and entitled "Stimulation of Adenylate Cyclase by Water-Soluble Analogues of Forskolin".
S. P. Bartels, et al., Current Eye Research, 2, 673 (Feb. 1983), published in the U.K. and entitled "Forskolin stimulated cyclic AMP synthesis, lowers intraocular pressure and increase outflow facility in rabbits".
K. Seamon and J. W. Daly, The Journal of Biological Chemistry, 256, 9799 (1981), published in the U. S. and entitled "Activation of Adenylate Cyclase by the Diterpene Forskolin Does Not Require the Guanine Nucleotide Regulatory Protein".
J. Takeda, et al., The Journal of Investigative Dermatology, 81, 236 (1983), published in the U. S. and entitled "Forskolin Activates Adenylate Cyclase Activity and Inhibits Mitosis in In Vitro in Pig Epidermis".
J. Takeda, et al., The Journal of Investigative Dermatology, 81, 131 (1983), published in the U. S. and entitled "Adenylate Cyclase Activation by Cholera Toxin in Pig Epidermis: An Obligatory Role of the GTP-Regulatory Protein".
R. J. Cherill, et al., Abstracts of Papers, 192nd and ACS National Meeting, Medi, No. 48 (Sep., 1986), published in the U. S. and entitled "Forskolin Derivatives as Anti-glaucoma Agents".
J. Caprioli and M. Sears, The Yale Journal of Biology and Medicine, 57, 283 (1984), published in the U. S. and entitled "The Adenylate Cyclase Receptor Complex and Aqueous Humor Formation".
K. B. Seamon and J. W. Daly, Trends in Pharmacological Sciences, 48, 120 (1983), published in the U. K. and entitled "Forskolin, cyclic AMP and cellular physiology".
K. B. Seamon and J. W. Daly, J. Cyclic Nucleotide Research, 7, 201 (1981) published in the U. S. and entitled "Forskolin: A Unique Diterpene Activator of Cyclic AMP-Generating Systems".
J. Caprioli, et al., Abstracts, Association for Research in Vision and Ophthalmology, 233 (1986-5:15), published in the U. S. and entitled "Cyclase Activation and IOP Reduction by Forskolin Analogs".
S. P. Bartels, et al., Current Eye Research, 6, 307 (1987), published in the U. K. and entitled "The effects of forskolin on cyclic AMP, intraocular pressure and aqueous humor formation in rabbits".
K. B. Seamon and J. W. Daly, in "Advances in Cyclic Nucleotide and Protein Phosphorylation Research", vol. 20, P. Greengard and G. A. Robison, Editors, Raven Press, New York, NY, 1986, pp. 1 to 150, published in the U. S. and entitled Forskolin: Its Biological and Chemical Properties.
N. J. de Souza, et al., Medicinal Research Reviews, 3, 201 (1983), published in the U. S. and entitled "Forskolin: A Labdane Diterpenoid with Antihypertensive, Positive Inotropic, Platelet Aggregation Inhibitory, and Adenylate Cyclase Activating Properties".
S. V. Bhat, et al., J. Med. Chem., 26, 486 (1983), published in the U. S. and entitled "The Antihypertensive and Positive Inotropic Diterpene Forskolin: Effects of Structural Modifications on Its Activity".
K. B. Seamon, et al., J. Med. Chem., 26, 436 (1983), published in the U. S. and entitled "Structure-Activity Relationships for Activation of Adenylate Cyclase by the Diterpene Forskolin and Its Derivatives".
S. V. Bhat, et al., Tetrahedron Letters, 1669 (1977), published in the United Kingdom and entitled "Structures and Stereochemistry of New Labdane Diterpenoids from Coleus Forskohlii Briq.".
S. V. Bhat, et al., J. C. S. Perkin I, 767 (1982), published in the United Kingdom and entitled "Reactions of forskolin, A Biologically Active Diterpenoid from Coleus Forskohlii".
J. Caprioli, et al., Investigative Ophthalmology and Visual Science, 25, 268 (1984) published in the U. S. and entitled "Forskolin Lowers Intraocular Pressure by Reducing Aqueous Inflow".
J. Caprioli and M. Sears, The Lancet, 958 (1983), published in the U.K. and entitled "Forskolin Lowers Intraocular Pressure in Rabbits, Monkeys, and Man".
K. B. Seamon, et al., Proc. Natl. Acad. Sci. USA, 78, 3363 (1981), published in the U. S. and entitled "Forskolin: Unique diterpene activator of adenylate cyclase in membranes and in intact cells".
K. M. Halprin, et al., The Journal of Investigative Dermatology, 65, 170 (1975) published in the U. S. and entitled "Cyclic AMP and Psoriasis".
W. P. Raab, International Journal of Clinical Pharmacology, Therapy and Toxicology, 18, 212 (1980); published in Germany and entitled "Cyclic nucleotides and prostaglandins in psoriasis".
H. Hzuka, et al., Biochimica et Biophysica Acta., 444, 685 (1976) published in The Netherlands and entitled "Adenosine and Adenine Nucleotides Stimulation of Skin (Epidermal) Adenylate Cyclase".
H. Hzuka, et al., Biochimica et Biophysica Acta., 437, 150 (1976) published in The Netherlands and entitled "Histamine (II.sub.2) Receptor-Adenylate Cyclase System in Pig Skin (Epidermis)".
J. J. Voorhees, The Journal of Investigative Dermatology, 59, 114 (1972), published in the U. S. and entitled "The Cyclic AMP System in Normal and Psoriatic Epidermis".
Cherill Robert Joseph
Kosley, Jr. Raymond W.
O'Malley Gerard
Collier Kenneth J.
Davis Zinna Northington
Hoechst Marion Roussel Inc.
Simmons Edlyn S.
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