Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2005-06-21
2005-06-21
Nashed, Nashaat T. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C435S194000, C530S350000
Reexamination Certificate
active
06908754
ABSTRACT:
A DNA fragment which encodes a polypeptide defined in the following (a) or (b), and a polypeptide defined in the following (c) or (d):(a) a polypeptide which has at least the amino acid sequence of the amino acid numbers 50 to 393 in SEQ ID NO: 2 shown in Sequence Listing,(b) a polypeptide which has at least the amino acid sequence of the amino acid numbers 50 to 393 in SEQ ID NO: 2 shown in Sequence Listing including substitution, deletion, insertion, addition, or inversion of one or several amino acids, and can constitute a protein having a carbamoyl-phosphate synthetase activity with a large subunit of carbamoyl-phosphate synthetase having the amino acid sequence of SEQ ID NO: 3,(c) a polypeptide which has the amino acid sequence of SEQ ID NO: 3 shown in Sequence Listing,(d) a polypeptide which has the amino acid sequence of SEQ ID NO: 3 shown in Sequence Listing including substitution, deletion, insertion, addition, or inversion of one or several amino acids, and can constitute a protein having a carbamoyl-phosphate synthetase activity with a small subunit of carbamoyl-phosphate synthetase having the amino acid sequence of the amino acid numbers 50 to 393 in SEQ ID NO: 2.
REFERENCES:
patent: 6255086 (2001-07-01), Kuwabara et al.
patent: 0 077 548 (1983-04-01), None
patent: 0 261 6627 (1988-03-01), None
patent: WO 95/03417 (1995-02-01), None
M. Crabeel, et al., Journal of Bacteriology, vol. 143, No. 2, pp. 921-925, “use of Gene Cloning to Determine Polarity of an Operon: Genes Carab ofEscherichia coli”, Aug. 1980.
M. Mergeay, et al., Molec. Gen. Genet., pp. 299-316, “Physiology and Genetics of Carbamoylphosphate Syntesis inEscherichia coliK12”, 1974.
J. Piette, et al., Proc. Natl. Acad. Sci. USA, vol. 81, pp. 4134-4138, “DNA Sequence of the Cara Gene and the Control Region of Carab: Tandem Promoters, Prespectively Controlled by Arginine and the Pyrimidines, Regulate the Systhesis of Carbamoyl-Phosphate Synthetase inEscherichia coliK-12”, Jul. 1984.
H. Yang, et al., Eur. J. Biochem. vol. 249, pp. 443-449, “Cloning and Characterization of the Arginine-Specific Carbamoyl-Phosphate Synthetase fromBacillus stearothermophilus”, 1997.
M. Tuchman, et al. Applied and Environmental Microbiology, vol. 63, No. 1, pp. 33-38 “Enhanced Production of Arginine and Urea by Genetically EngineeredEscherichia coliK-12 Strains”, Jan. 1997.
G. Deckert, et al., Carbamoyl Phosphate Synthetase Small Subunit, 1 page, “the Complete Genome of the Hyperthermophilic BacteriumAquifex aeolicus,” Aug. 1, 1998, Database:EMBL, Accession No. 066727.
S. Tabata, Carbamoyl-phosphate Synthease, Pyrimidine-specific, Large Chain, 2 pages, “Sequence Analysis of the Genome of the Unicellular Cyanobacterium,” Biv, 1, 1996, Database EMBL, Accession No. Q55756.
K. Matsui, et al., Agricultural and Biological Chemistry, vol. 51, No. 3, pp. 823-828, XP-001160768, “Cloning of Tryptophan Genes of Brevibacterium Lactofermentum, A Glutamic Acid-Producing Bacterium”, 1987.
J. P. Schofield, et al., Clinical Science, Biochemical Society and the Medical Research Society, vol. 84, No. 2, pp. 119-128, XP-002038834, “Molecular Studies on an Ancient Gene Encoding for Carbamoyl-Phosphate Synthetase”, Aug. 25, 1997.
F. S. Lawson, et al., Microbiology, vol. 141, pp. 1183-1191, XP-008020579, “Organization of Carbamoyl-Phosphate Synthase Genes inNeisseria GonorrhoeaeIncludes a Large, Variable Intergenic Sequence Which is also Present in OtherNeisseriaSpecies”, 1995.
A. Elagöz, et al., Gene an International Journal on Genes and Genomes, vol. 182, pp. 37-43, “Structure and Organisation of the Pyrimidine Biosynthesis Pathway Genes inLactobacillus plantarum: a PCR Strategy for Sequencing Without Cloning”, Dec. 1996.
M. Kilstrup, et al., Database Biosis, Biological Abstracts Inc., US, Biosis, 1 page, an Prev198886113458, “Nucleotide Sequence of the Cara Gene and Regulation of Carab Operon inSalmonella-typhimurium”, 1988.
H. Yang, et al., Database Biosis, Biological Abstracts Inc., US, Biosis, 2 pages an Prev 199799812800, “Cloning and Characterization of the Arginine-Specific Carbamoyl-Phosphate Synthetase fromBacillus Stearothermophilus”, 1997
Hashiguchi Ken-ichi
Ito Hisao
Kurahashi Osamu
Kuwabara Yoko
Mori Yukiko
Ajinomoto Co. Inc.
Nashed Nashaat T.
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