Carbamoyl derivatives

Details Carbamoyl derivatives Carbamoyl derivatives

1992-08-10

1994-02-15

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548503, A61K 3140, C07D20908

Patent

active

052867404

ABSTRACT:
The present invention concerns novel carbamoyl derivatives of formula I, set out herein, which antagonize the pharmacological actions of one or more of the arachidonic acid metabolites known as leukotrienes, making them useful whenever such antagonism is desired, such as in the treatment of those diseases in which leukotrienes are implicated, for example, in the treatment of allergic or inflammatory diseases, or of endotoxic or traumatic shock conditions. The invention also provides pharmaceutical compositions containing the novel derivatives for use in such treatments, methods for their use and processes and intermediates for the manufacture of the novel derivatives.

REFERENCES:
patent: 4918094 (1990-04-01), Bernstein et al.
Gassen, Karl-Rudolf et al., Chem. Ber., (1986), 119, 2233-2248.

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