Carbamoyl derivatives

Details Carbamoyl derivatives Carbamoyl derivatives

1993-10-14

1994-08-02

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C21103

Patent

active

053347650

ABSTRACT:
The present invention concerns novel carbamoyl derivatives of formula I, set out herein, which antagonize the pharmacological actions of one or more of the arachidonic acid metabolites known as leukotrienes, making them useful whenever such antagonism is desired, such as in the treatment of those diseases in which leukotrienes are implicated, for example, in the treatment of allergic or inflammatory diseases, or of endotoxic or traumatic shock conditions. The invention also provides pharmaceutical compositions containing the novel derivatives for use in such treatments, methods for their use and processes and intermediates for the manufacture of the novel derivatives.

REFERENCES:
patent: 4918094 (1990-04-01), Bernstein et al.
Chem. Ber. 119, 2233-2248, Gassen et al., 1986.
CA 115 (17): 183090g Preparation of . . . antagonists, Jacobs, pp. 903-904, 1991.
CA 117(15):150542b (2R)-methyl-4,4,4-trifluorobutylamine Jacobs et al., p. 784, 1992.
CA 117(15):150884q 3-Alkylated indoles Jacobs et al., p. 816, 1992.

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