Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-08-09
2011-08-09
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S406000
Reexamination Certificate
active
07994179
ABSTRACT:
DGAT-1 inhibitor compounds of formula (I), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesitywherein, for example,Ring A is optionally substituted 2,6-pyrazindiyl;X is ═O;Ring B is optionally substituted 1,4-phenylene;Y1is a direct bond or —O—;Y2is —(CH2)r— wherein r is 2 or 3;n is 0 or n is 1 when Y1is a direct bond between Ring B and Ring C and when Ring B is 1,4-phenylene and Ring C is (4-6C)cycloalkane;Ring C is optionally substituted (4-6C)cycloalkane, (7-10C)bicycloalkane, (8-12C)tricycloalkane, phenylene or pryidindiyl;L is a direct bond or —O—;p is 0, 1 or 2 and when p is 1 or 2 RA1and RA2are each independently hydrogen or (1-4C)alkyl;Z is carboxy or a mimic or bioisostere thereof.
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Birch Alan Martin
Butlin Roger John
Johannesson Petra
Johansson Jan Magnus
Petersson Annika Ulrika
Astrazeneca AB
Morgan & Lewis & Bockius, LLP
Willis Douglas M
Wilson James O
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