Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-05-25
1995-10-03
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514253, 514307, 514318, 514339, 544124, 544364, 546147, 546193, A61K 3144, C07D40112
Patent
active
054552451
ABSTRACT:
This invention relates to compounds of the formula ##STR1## where R.sub.1 -R.sub.6, X and Y are as defined in the specification, which are useful for the treatment of various memory dysfunctions characterized by a cholinergic deficit and thus may be indicated in the treatment of Alzheimer's disease.
REFERENCES:
patent: 3679692 (1972-07-01), Wu
patent: 3862953 (1975-01-01), Berger
patent: 4699907 (1987-10-01), Gasc
patent: 4880822 (1989-11-01), Effland
patent: 5006537 (1991-04-01), Effland
patent: 5021438 (1991-06-01), Junge
patent: 5039811 (1991-08-01), Effland
patent: 5102891 (1992-04-01), Effland
patent: 5177088 (1993-01-01), Effland
patent: 5214038 (1993-05-01), Effland
A. K. Sheinkman, et al. Chemical Abstracts 70, 19857b (1969).
T. K. Murray, et al., Psychopharmacology 105, 134 (1991) entitled "Reversal by Tetrahydroaminoacridine of Scopolamine-induced Memory and performance deficits in Rats", and published in the United States of America.
Nat'l Institute of Mental Health Publication #ADM90-1696 (1990) entitled "Useful Information on Alzheimer's Disease" & published in the USA.
James F. Flood, et al., Brain Research, 215, 177 (1981), entitled "Cholinergic Receptor Interactions and their Effects on Long-Term Memory Processing", and published in the Netherlands.
James F. Flood, et al., Psychopharmacology, 86, 61 (1985) entitled "Memory Enhancement: Supra-additive Effect of Subcutaneous Cholinergic Drug Combinations in Mice", and published in the USA.
Paul E. Gold, Behavioral and Neural Biology, 46, (1986), entitled "The Use of Avoidance Training in Studies of Modulation of Memory Storage" and published in the USA.
Paul E. Gold, Animal Learning & Behavior, 17, 94 (1989), entitled "Neurobiological Features Common to Memory Modulation by Many Treatments" and published in the USA.
Davis Larry
Effland Richard C.
Olsen Gordon E.
Chang Ceila
Hoechst-Roussel Pharmaceuticals Inc.
Wittekind Raymond R.
LandOfFree
Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1077505