Carbamic acid ester useful for preparing a nucleic acid probe

Details Carbamic acid ester useful for preparing a nucleic acid probe Carbamic acid ester useful for preparing a nucleic acid probe

1987-07-13

1989-02-07

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

548303, C07C12506

Patent

active

048032972

ABSTRACT:
Nucleic acids may be labeled by intercalating the alkylating intercalation moiety of a labeling reagent into a partially double-stranded nucleic acid to form a complex and activating the complex to cause covalent bonding between the reagent and the nucleic acid. Preferably, the labeled nucleic acid is hybridization probe for detecting nucleic acid sequences capable of hybridizing with a hybridizing region of the nucleic acid. Also preferably the label moiety is non-radioactive. The labeling reagent is of the formula:

REFERENCES:
patent: 4124598 (1978-11-01), Hearst et al.
patent: 4582789 (1986-04-01), Sheldon et al.
patent: 4617261 (1986-10-01), Sheldon et al.
Saffran et al., Proc. Natl. Acad. Sci., U.S.A., 79, 4594-4598, (1982).
Schwartz et al., CSH Laboratory Symposium XLVII.

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