Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1987-07-13
1989-02-07
Lee, Mary C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
548303, C07C12506
Patent
active
048032972
ABSTRACT:
Nucleic acids may be labeled by intercalating the alkylating intercalation moiety of a labeling reagent into a partially double-stranded nucleic acid to form a complex and activating the complex to cause covalent bonding between the reagent and the nucleic acid. Preferably, the labeled nucleic acid is hybridization probe for detecting nucleic acid sequences capable of hybridizing with a hybridizing region of the nucleic acid. Also preferably the label moiety is non-radioactive. The labeling reagent is of the formula:
REFERENCES:
patent: 4124598 (1978-11-01), Hearst et al.
patent: 4582789 (1986-04-01), Sheldon et al.
patent: 4617261 (1986-10-01), Sheldon et al.
Saffran et al., Proc. Natl. Acad. Sci., U.S.A., 79, 4594-4598, (1982).
Schwartz et al., CSH Laboratory Symposium XLVII.
Levenson Corey H.
Mullis Kary B.
Cetus Corporation
Halluin Albert P.
Hasak Janet E.
Lee Mary C.
Whittenbaugh Robert C.
LandOfFree
Carbamic acid ester useful for preparing a nucleic acid probe does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Carbamic acid ester useful for preparing a nucleic acid probe, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carbamic acid ester useful for preparing a nucleic acid probe will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1085690