Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-02-28
1991-05-21
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540594, 540595, C07D22316, A61K 3155
Patent
active
050175718
ABSTRACT:
Compounds having the formula ##STR1## wherein R.sup.1, R.sup.4, R.sup.6, R.sup.7, and R.sup.8 are hydrogen or a substituent, R.sup.2 is a substituent, R.sup.5 is an optionally-substituted bicyclic ring system, especially a 7-benzofuranyl or 2,3-dihydrobenzofuran-7-yl substituent, R.sup.9 is hydrogen, alkyl, alkoxycarbonyl or, together with R.sup.8, forms the remainder of a heterocyclic ring, their pharmaceutically-accceptable salts, as well as their pharmaceutical compositions and use as prodrugs for compounds active for the treatment of mental disorders, are disclosed.
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patent: 4284555 (1981-08-01), Gold et al.
patent: 4751222 (1988-06-01), Braestrup et al.
Charton, M., "Prodrug Liability Prediction through the use of Substituent Effects", Methods in Enzymology, vol. 112 (1985), pp. 323-340.
Bundgaard Hans
Faarup Peter
Hansen Kristian T.
Datlow Philip
Hueschen Gordon W.
Novo Nordisk A S
Shah Mukund J.
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