Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-11-03
1996-01-30
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540581, 540587, C07D51304, C07D49804, A61K 3155
Patent
active
054880467
ABSTRACT:
The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E.sub.2 antagonists for the treatment of prostaglandin-E.sub.2 mediated diseases, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, a method for eliminating or ameliorating pain in an animal, and a method for treating prostaglandin-E.sub.2 mediated diseases in an animal, comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
REFERENCES:
patent: 2852528 (1958-09-01), Hoffmann et al.
patent: 3210372 (1965-10-01), Werner et al.
patent: 3357998 (1967-12-01), Cusic et al.
patent: 3534019 (1970-10-01), Coyne et al.
patent: 3624104 (1971-11-01), Cusic et al.
patent: 3809698 (1974-05-01), Yale et al.
patent: 3856781 (1974-12-01), Yale et al.
patent: 3856782 (1974-12-01), Yale et al.
patent: 3875166 (1975-04-01), Yale et al.
patent: 3917649 (1975-11-01), Mueller
patent: 3989719 (1976-11-01), Mueller
patent: 3992375 (1976-11-01), Mueller
patent: 4045442 (1977-08-01), Mueller
patent: 4125532 (1978-11-01), Mueller
patent: 4170593 (1979-10-01), Mueller
patent: 4290953 (1981-09-01), Koizumi et al.
patent: 4360525 (1982-11-01), Muller
patent: 4379150 (1983-04-01), Ito et al.
patent: 4559336 (1985-12-01), Mueller
patent: 4559337 (1985-12-01), Mueller
patent: 4614617 (1986-09-01), Mueller
patent: 4681939 (1987-07-01), Mueller
patent: 4704386 (1987-11-01), Mueller
patent: 4888335 (1989-12-01), Mohrbacher et al.
patent: 5180720 (1993-01-01), Husa et al.
patent: 5182272 (1993-01-01), Hallinan et al.
patent: 5212169 (1993-05-01), Husa et al.
A. Bennett, et al. "Antagonism of Prostanoid-Induced Contractions of Rat Gastric Fundus Muscle by SC-19220 Sodium Meclofenamate, Indomethacin or Trimethoquinol," Br. J. Pharmac., 71, 169-175 (1980)--London.
W. E. Coyne, et al. "Anticonvulsant Semicarbazides," J. Med. Chem., 11(6), 1158-1160 (1968)--USA.
E. J. Drower, et al. "The Antiociceptive Effects of Prostaglandin Antagonists in the Rat, " European Journal of Pharmacology, 133, 249-256 (1987)--Europe.
F. R. George, et al. "Antagonism of Alcohol Hypnosis by Blockade of Prostaglandin Synthesis and Activity: Genotype and Time Course Effects," Pharmacology, Biochemistry & Behavior, vol. 19, 131-136 (1983)--USA.
R. Gimet, et al. "Quantitative Determination of Polymorphic Forms in a Formulation Matrix Using the Near Infra-Red Reflectance Analysis Technique," Journal of Pharmaceutical & Biomedical Analysis, vol. 5, No. 3, 205-211 (1987)--Great Britain.
A. Gomes, et al. "Pharmacodynamics of Venom of the Centipede Scolopendra Subspinipes Dehaani," Indian Journal of Experimental Biology, vol. 20, 615-618, Aug. (1982)--India.
K. Gyires, et al. "The Use of the Writhing Test in Mice for Screening Different Types of Analgesics," Arch. Int. Pharmacodyn, 267, 131-140 (1984)--USA.
D. E. Macintyre, et al. "Antagonism of Human Platelet Responses to Stimulatory and Inhibitory Prostaglandins," Prog. Lipid. Res., 20 (1-4), 453-9 (1981)--USA.
C. A. Maggi, et al. "The Effect of SC-19220, a Prostaglandin Antagonist, on the Micturition Reflex in Rats," European Journal of Pharmacology, 152, 273-279 (1988)--Europe.
K. Nagarajan, et al. "Synthesis of 10,11-Dihydrodibenz[b,f][1,4]oxazepine Derivatives as Potential Anticonvulsant & Psychotropic Agents," Indian Journal of Chemistry, vol. 24B, 840-844 (1985)--India.
S. Nakajyo, et al. "Inhibitory Effect of Bassianolide, a Cyclodepsipeptide, on Drug-Induced Contractions of Isolated Smooth Muscle Preparations," Japan J. Pharmacol., 32, 55-64 (1982)--Japan.
A. Rakovska, et al. "Antagonistic Effect of SC-19220 on the Responses of Guinea-Pig Gastric Muscles to Prostaglandins E.sub.1, E.sub.2, and F.sub.2.alpha.," Arch. Int. Pharmacodyn., 268, 59-69 (1984)--USA.
J. H. Sanner "Dibenzoxazepine Hydrazides as Prostaglandin Antagonists," Intra-Science Chem. Rept., vol. 6, No. 1, 1-9 (1972)--USA.
J. H. Sanner, et al. "Structure-Activity Relationships of Some Dibenzoxazepine Derivatives as Prostaglandin Antagonists," Advances in the Biosciences, 9, 139-148 (1972)--USA.
Chrusciel Robert A.
Hagen Timothy J.
Hallinan E. Ann
Li Jinglin
Reitz David B.
Bond Robert T.
G. D. Searle & Co.
Hastreiter Roberta L.
Williams Roger A.
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