Carbamates of 2-haloergolines and 2-haloergolenes and process fo

Details Carbamates of 2-haloergolines and 2-haloergolenes and process fo Carbamates of 2-haloergolines and 2-haloergolenes and process fo

1978-01-30

1980-04-22

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424250, 424261, 544125, 544361, 546 67, C07D45702, A61K 3148

Patent

active

041995791

ABSTRACT:
A number of pharmacologically active ergoline derivatives are disclosed, their preparation is described and examples of suitable pharmaceutical preparations are presented. Of quite particular interest among the rich series of compounds afforded by the present invention are D-2-bromo-1,6-dimethyl-8beta-(perhydroazepinylcarbonyloxymethyl)-ergoline and its salts (especially maleate and methanesulfonate) for the treatment of psychogenetic disorders, and D-2-bromo-6-methyl-8beta-(morpholinocarbonyloxymethyl)-ergoline and its salts (especially the maleate and the methanesulfonate for the treatment of asthma and allied ailments. Good tolerability, low toxicity and high effectiveness distinguish these compounds over those of the prior art.

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patent: 4057635 (1977-11-01), Ferrari et al.
Troxler et al., Helv. Chim. Acta vol. 40, pp. 2160-2170 (1957).

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