Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-01-23
1998-04-28
Davis, Zinna Northington
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142372, 514314, 514315, 514330, 546153, 546192, 546193, 546194, 546245, 544129, C07D21132, A61K 31445
Patent
active
057444854
ABSTRACT:
The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer therapy.
REFERENCES:
Callens, Bull Soc. Chim Belg. vol. 91, No. 8, pp. 713-723, 1982.
Tozuka et al., J. of Antibiotics, vol. XXXVI, No. 12, pp. 1699-1708, 1983.
Chemical Abstracts, vol. 116, Abstract No. 256054p, Jun. 22, 1992.
Harding Matthew W.
Zelle Robert Edward
Davis Zinna Northington
Haley, Jr. James F.
Vertex Pharmaceuticals Incorporated
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