Carbamate salts of 2-(2'-thienyl)alkylamines

Details Carbamate salts of 2-(2'-thienyl)alkylamines Carbamate salts of 2-(2'-thienyl)alkylamines

1990-01-25

1991-03-05

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 76, C07D49504, C07D33020

Patent

active

049979450

ABSTRACT:
The carbamate salt of 2-(2'-thienyl)-alkylamines and particularly the ethylamine and its method of synthesis are disclosed. The carbamate salt of 2-(2'-thienyl)ethylamine is a stable, easily transportable crystalline material that can be converted to 2-(2'-thienyl)ethylamine, a useful intermediate in the synthesis of 5[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno-[3,2-c]pyridine hydrochloride, also known as ticlopidine hydrochloride. The synthesis is carried out by reacting an amine of formula (I): ##STR1## with CO.sub.2 in a hydrocarbon solvent to obtain the carbamate salt of formula II: ##STR2##

REFERENCES:
patent: 4051141 (1977-09-01), Castaigne

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