Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-07-11
2006-07-11
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S224800, C514S254080, C514S254090, C514S298000, C514S411000, C514S415000, C540S589000, C544S031000, C544S375000, C546S109000, C548S441000, C548S491000, C548S510000
Reexamination Certificate
active
07074782
ABSTRACT:
This invention provides caspase inhibitors of formula I:wherein Z is oxygen or sulfur; R1is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; Y is an electronegative leaving group; R2is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R3is a group capable of fitting into the S2 subsite of a caspase enzyme; R4and R5are taken together with the intervening nitrogen to form heterocyclic ring and R is as described in the specification. The compounds are effective inhibitors of apoptosis and IL-1β secretion.
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Bebbington David
Golec Julian M. C.
Kay David
Knegtel Ronald
Mortimore Michael
Badia Michael C.
Dixon Lisa A.
Kifle Bruck
Vertex Pharmaceuticals Incorporated
Vertex Pharmaceuticals Incorporated
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