Carbacyclin derivatives, method of manufacturing the same and th

Details Carbacyclin derivatives, method of manufacturing the same and th Carbacyclin derivatives, method of manufacturing the same and th

1987-06-01

1988-03-08

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549434, 560119, 560 56, C07C17700

Patent

active

047300604

ABSTRACT:
New agents of carbacyclin derivatives are disclosed, which are represented by the following formula: ##STR1## wherein A is a --CH.dbd.CH-- or --C.tbd.C-- group. B is a substituted or unsubstituted indanyl group, substituted or unsubstituted benzodioxanyl group, substituted or unsubstituted benzodioxolanyl group or 2,3,5,6,7, 8-hexahydrobenzodioxanyl group. D is --CH.sub.2 -- or --O--. .about.OH group represents .alpha. or .beta. configuration of OH group; and ##STR2## These compounds are useful as anit-ulcer, anti-hypertensive or anti-thrombotic agents.

REFERENCES:
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patent: 4533749 (1985-08-01), Aristoff
patent: 4618626 (1986-10-01), Skuballa
Tobimatsu, M. et al, Fac. Med. Kyushu Univ. Ann Surg., 205(2) 199-202, 1987.
Adaikan, P. G. et al; Prostaglandins, Leukotrienes, Med 10(1), 53-64, 1983.

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