Carbacyclin derivatives

Details Carbacyclin derivatives Carbacyclin derivatives

1986-03-18

1988-07-12

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560119, 562501, C07C 6232, A61K 3121

Patent

active

047570873

ABSTRACT:
Carbacyclin derivatives with anti-ulcer activity comprise compounds of the general formula (I): ##STR1## (wherein R.sup.1 is selected from the group consisting of a hydrogen atom and an alkyl group having from 1 to 10 carbon atoms; R.sup.2 is selected from the group consisting of a hydrogen atom and a methyl group; and R.sup.3 is selected from the group consisting of a 3-butenyl group, a 4-pentenyl group and a 5-methyl-4-hexenyl group), and pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 4238414 (1980-12-01), Morton, Jr.
patent: 4338457 (1982-07-01), Aristoff
patent: 4628110 (1986-12-01), Aristoff
The American Heritage Dictionary, Second college edition, Houghton Mifflin Company, U.S.A., 1982, p. 81.
Brodie and Chase, Gastroenterology, vol. 53, No. 4 - "Role of Gastric Acid in Aspirin-Induced Gastric Irritation in the Rat".

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