Carbacyclin analogs

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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568807, 568808, 560 56, 424308, 424317, 560 28, 562451, 562452, 562455, 260239BF, 260465F, 260465D, 544154, 544171, 544176, 544336, 544386, 546203, 546205, 546285, 546309, 546314, 546337, 548280, 548528, 564 80, 564 88, 564 90, 564 95, 564172, 564174, 564158, 568632, 568633, 568634, 568734, C07C17700, A61K 31557

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active

044865988

ABSTRACT:
Novel compounds of the following general formula: ##STR1##

REFERENCES:
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patent: 4192891 (1980-03-01), Haslanger
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patent: 4306075 (1981-12-01), Aristoff
patent: 4306076 (1981-12-01), Nelson
Aristoff, P. A., J. Org. Chem. 46 (No. 9), 1981, pp. 1954-1957 "Practical Synthesis of 6a-Carbaprostaglandin I.sub.2 ".
Barco, A., et al., J. Org. Chem. 45 (No. 23), 1980, pp. 4776-4778 "A New Elegant Route to a Key Intermediate for the Synthesis of 9(O)-Methanoprostacyclin".
Hayashi, M., et al., Chem. Lett. 1979, pp. 1437-1440 "A Synthesis of 9(O)-Methanoprostacyclin".
Kojima, K., et al., Tetrahedron Lett. 39, 1978, pp. 3743-3746 "Total Synthesis of 9(O)-Methanoprostacyclin and Its Isomers".
Morton, D. R., Jr., et al., J. Org. Chem. 44 (No. 16), 1979, pp. 2880-2887 "Total Synthesis of 6a-Carbaprostaglandin I.sub.2 and Related Isomers".
Nicolaou, K. C., et al., J.C.S. Chem. Comm., 1978, pp. 1067-1068 "Total Synthesis of Carboprostacyclin, a Stable and Biologically Active Analogue of Prostacyclin(PGI.sub.2)".
Shibasaki, M., et al., Chem. Lett. 1979, pp. 1299-1300 "A Stereo and Regiospecific Route to the Synthetic Intermediate for the Synthesis of 9(O)-Methanoprostacyclin".
Shibasaki, M., et al., Tetrahedron Lett. 5, 1979, pp. 433-436 "New Synthetic Routes to 9(O)-Methanoprostacyclin, A Highly Stable and Biologically Potent Analog of Prostacyclin".
Skuballa, W., et al., Angew. Chem. 93 (No. 12), 1981, pp. 1080-1081 "Ein neuer Weg zu 6a-Carbacyclinen-Synthese eines stabilen, biologisch potenten Prostacyclin-Analogons".
Sugie, A., et al., Tetrahedron Lett. 28, 1979, pp. 2607-2610 "Stereocontrolled Approaches to 9(O)-Methanoprostacyclin".
Yamazaki, M., et al., Chem. Lett. 1981, pp. 1245-1248 "1,2-Carbonyl Transposition of cis-Bicyclo[3.3.0]octan-2-one to Its 3-one Skeleton: Application to Syntheses of dl-Hirsutic Acid and dl-9(O)-Methanoprostacyclin".

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