Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1979-08-13
1981-01-13
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125S, A61K 3700, C07C10352
Patent
active
042449472
ABSTRACT:
Peptides of formula I ##STR1## in which X is (CH.sub.2).sub.2, S--CH.sub.2 or CH.sub.2 --S or a therapeutically acceptable acid addition salt thereof are disclosed. The peptides of formula I are useful as agents for the treatment of acromegaly and the management of diabetes in a mammal. Compositions and methods for the preparation of the peptides of formula I are also disclosed.
REFERENCES:
patent: 4020157 (1977-04-01), Immer et al.
patent: 4115554 (1978-09-01), Veber
patent: 4161521 (1979-07-01), Veber et al.
J. Rivier, et al., "Peptides" 1976 427-451.
J. E. Rivier, et al., J. Med. Chem. 19, 1010 1976.
Abraham Nedumparampil A.
Bellini Francesco
Immer Hans U.
Kobric Marvin M.
Ayerst McKenna and Harrison Inc.
Phillips Delbert R.
Wilfond Arthur E.
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