Capture sandwich hybridization method and composition

Details Capture sandwich hybridization method and composition Capture sandwich hybridization method and composition

1992-10-30

1994-02-22

Rollins, John W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435803, 436520, 436527, 436533, 935 78, C12Q 168, G01N 33555, G01N 33552, G01N 33546

Patent

active

052886093

ABSTRACT:
This invention provides methods and compositions for the detection of a target genetic material having a desired base sequence or gene. Also disclosed are methods and compositions for the detection of mutants. The methods and compositions are based in part upon techniques which utilize two labeled single-stranded polynucleotide segments which are complementary to different portions of the genetic material. The methods and compositions of this invention result in the formation of a double hybrid and/or multihybrid, and can furthermore be employed in an attached system, i.e., a matrix-bound entity capable of binding to a polynucleotide probe entity.

REFERENCES:
patent: 4486539 (1984-12-01), Ranki et al.
Long and Dawid, Cell 18:1185-1196 (1979).
Kimmel and Firtel, Cell 16:787-796 (1979).
Dunn and Hassell, Cell 12:23-26 (1977).
Ranki et al., Gene 21:77-85 (1983).
Ranki et al., Current Topics in Microbiology and Immunology 104:307-318 (1983).
Ranki et al., Chemical Abstracts (CA), 99(13):101864j (1983).

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