Capture, recapture, and trapping of molecules with a nanopore

Details Capture, recapture, and trapping of molecules with a nanopore Capture, recapture, and trapping of molecules with a nanopore

2011-08-30

2011-08-30

Forman, Betty (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S283100, C435S258200, C435S286100, C435S288500, C422S068100, C422S082010, C536S023100, C977S924000, C977S932000, C977S953000, C977S958000

Reexamination Certificate

active

08008014

ABSTRACT:
In a molecular analysis system, there is provided a structure including a nanopore and first and second fluidic reservoirs. The two reservoirs are fluidically connected via the nanopore. A detector is connected to detect molecular species translocation of the nanopore, from one of the two fluidic reservoirs to the other of the two fluidic reservoirs. A controller is connected to generate a control signal to produce conditions at the nanopore to induce the molecular species to re-translocate the nanopore at least once after translocating the nanopore. This enables a method for molecular analysis in which a molecular species is translocated a plurality of times through a nanopore in a structure between two fluidic reservoirs separated by the structure.

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