Combinatorial chemistry technology: method – library – apparatus – Library – per se
Reexamination Certificate
2002-07-16
2010-12-28
Lundgren, Jeffrey S (Department: 1639)
Combinatorial chemistry technology: method, library, apparatus
Library, per se
C506S007000, C506S023000
Reexamination Certificate
active
07858560
ABSTRACT:
Capture Collections of capture compounds and collections thereof and methods using the compounds collections for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds in the collections are multifunctional reagents that provide for the separation and isolation of biomolecules in complex protein mixtures. In the collections, each and every compound in the collection, has the formula:Z is a trityl derivative, each of m and n independently is an integer that is 1 to 100; X, the reactivity function, covalently binds to amino acid side chains of biomolecules; Y, the selectivity function, modulates binding of X to the amino acid side chains in biomolecules such that X binds to fewer biomolecules when the selectivity moiety Y is present than in its absence; and Q permits separation or immobilization of capture compounds in the collection. Automated systems for performing the methods also are provided.
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Köster Hubert
Little Daniel P.
Siddiqi Suhaib
caprotec bioanalytics GmbH
K & L Gates LLP
Lundgren Jeffrey S
Seidman Stephanie
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