Capture assay utilising a particulate analyte

Details Capture assay utilising a particulate analyte Capture assay utilising a particulate analyte

2007-07-31

2007-07-31

Chin, Christopher L. (Department: 1641)

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

Separation of immune complex from unbound antigen or antibody

C422S051000, C422S051000, C422S067000, C422S073000, C422S105000, C435S007200, C435S007210, C435S287100, C435S287200, C435S287700, C435S288400, C435S288500, C435S805000, C435S810000, C435S970000, C436S514000, C436S525000, C436S536000, C436S810000

Reexamination Certificate

active

10240652

ABSTRACT:
Device (1) for assaying a particulate analyte, comprising (a) a receptacle (2) for receiving a suspension (5) of particulate analyte, and containing label (3) for the particulate analyte, and (b) a porous detection material (4) that is permeable to label (3) but is impermeable to particulate analyte, the detection material (4) being arranged within receptacle (2) such that introduction of suspension (5) of particulate analyte into receptacle (2) forms liquid communication between label (3) and detection material (4). After liquid sample (5) is introduced into the receptacle (2), capillary flow through the porous detection material (4) begins. Particulate analyte cannot flow through the detection material (4) and is captured at its surface. Addition of liquid sample (5) also releases the label (3) within the receptacle (2), which is then free to flow through the detection material (4). Label (3) encounters the captured analyte and gives a signal (7). Label is prevented from running ahead of the analyte, resulting in high sensitivity.

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