Capsule product containing high dosage of aspirin in powder or g

Details Capsule product containing high dosage of aspirin in powder or g Capsule product containing high dosage of aspirin in powder or g

1981-06-18

1982-07-13

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 16, 424 19, 424 37, 424154, 424155, 424156, 424157, 424158, 424230, 424235, A61K 948, A61K 920, A61K 3160, A61K 3306

Patent

active

043394280

ABSTRACT:
A capsule product preferably containing a high dosage of aspirin in powder or granulated form and at least one akaline tablet or pellet; the improvement in which said alkaline tablet or pellet comprises magnesium carbonate, calcium carbonate and a magnesium oxy component such as magnesium oxide, magnesium hydroxide or the combination of magnesium oxide and magnesium hydroxide. The alkaline tablet is preferably dimensioned so that it will contain a maximum amount of material in a minimum volume e.g. a spheroid so that it can be readily dropped into a gelatin capsule e.g. #0 gelatin capsule.

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Bandelin et al., J.A. Ph. A. 19(3):152-153 Mar. 1958 Prac. Phycd., "How Antacid Compounds Influence the Stability of Acetylsalicyclic Acid".
Simon Chem. Abstr. 25, #5932 .sup.8 (1931) of J. Lab. Clin. Med. 16:1064-6 (1931), "A Clinical Comparison of Acetylsalicyclic Acid Analgesia With and Without Magnesium Oxide".
Husa et al., J. A. Ph. A. 31:213-216 (1942) 29:78-86, 136-141 (1940), Incompatabilities in Prescriptions III The Use of Inert Powders in Capsules to Prevent Liquefaction Due to Formation of a Eutoctic Mixture IV Deliquescence V to Prevent Liquefaction.
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Conine; J. Pharm. Sci. 54:1580-85, 1965.
A. Baptisti, Arch. int. Pharmacodyn, 1966, 159, No. 1 234-239.

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