Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1994-04-21
1995-10-10
Phelan, D. Gabrielle
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424453, 424454, 427 221, 427 222, A61K 948
Patent
active
054569192
ABSTRACT:
A tamper-resistant dosage form capsule for the oral administration of therapeutic agents comprises a two-part capsule which is shrunk around a caplet so that the outer wall of the caplet is bound to the inner walls of both parts of the capsule. The caplet is placed into the capsule, and the dosage form is then subjected to relatively high humidity and temperature conditions, followed by drying the dosage form in a lower humidity environment, so that the capsule is shrunk to conform to the contours of the caplet and both parts of the capsule are bonded to the caplet.
REFERENCES:
patent: 4591500 (1986-05-01), Scapinelli
patent: 4820524 (1989-04-01), Berta
patent: 4851230 (1989-07-01), Tencza
patent: 4928840 (1990-05-01), Barshay
patent: 4936074 (1990-06-01), Graham
patent: 5314537 (1994-05-01), Berta
Frunzi Gerard
Merkle F. Henry
Patell Mahesh
Tencza Thomas
Bristol--Myers Squibb Company
Phelan D. Gabrielle
Santini Anthony M.
Zeller Charles J.
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